December 10: A Stage Show Entertainment Leads to the Discovery of Anesthesia



On December 10, 1844, Hartford residents were treated to a special performance of famous showman and former medical student Gardner Colton’s “Laughing Gas Entertainment.” Colton had first encountered “laughing gas,” or nitrous oxide, while in medical school and soon found he could make quite a bit of money traveling the country demonstrating its hilarity-inducing side effects. On that particular evening, 29-year-old Hartford dentist Horace Wells happened to be in the audience. Wells noticed that during the demonstration, one of Colton’s gassed-up volunteers had stumbled and slammed his leg against a bench and literally “laughed it off,” noting that he felt no pain from the incident even after the effects of the gas wore off.

A plaque honoring Horace Wells, located on Asylum Avenue in Hartford, near the location of Wells’ dental practice.

Wells immediately thought of the incredible benefit that such a phenomenon could provide to  dentistry, where painful tooth extractions and oral surgeries were the norm. The very next day, Wells summoned Colton to his Hartford office and had him administer nitrous oxide  while a dental assistant extracted one of Wells’ own wisdom teeth. After the gas wore off, Wells declared he felt no more pain than “the prick of a pin” during the procedure — making his experiment the first successful application of medical anesthesia.

Wells began incorporating nitrous oxide in his dental practice with great success.  Though he proudly claimed to be the inventor of “pain-free dentistry,” he refused to seek a patent on any of his methods. He  believed  that freedom from pain should be a universal right that was “as free as the air.” Wells’ important  discovery, however, was soon followed by a series of crushing professional setbacks. During the most important demonstration of his career, before a huge audience at Boston’s Massachusetts General Hospital, Wells administered nitrous oxide to a patient and proceeded to extract a tooth — only to abort the procedure after the patient cried out, seemingly in pain. Though  the patient later admitted he actually had felt no pain despite his cries, Wells was booed and jeered by the audience and accused of being a fraud.

The Boston incident began a tragic downward spiral for Wells, who fell into a deep depression that ultimately forced him to close his dental practice. Within the span of only a few years, he was living in New York City, estranged from his wife and only son, and experimenting on himself with combinations of ether and chloroform. Wells  became addicted to the latter, which  increased his already erratic behavior. On his 33rd birthday, he was arrested for throwing sulfuric acid on two women in New York City. Wells was  thrown into prison. There, the medical pioneer’s life came to an end by his own hand.

While he struggled during his lifetime to find recognition for his discoveries, Horace Wells has since been widely honored and credited with both  the discovery and first successful application of medical anesthesia. Unbeknownst to Wells, 12 days before he took his life  the Parisian Medical Society had officially recognized him as the first man to discover and perform surgical operations without pain and awarded him  an honorary M.D.  Later in the 19th century, he  was recognized as the discoverer of modern anesthesia by both the American Dental Association and American Medical Association. There are several tributes to Horace Wells  in Hartford, including a statue in Bushnell Park and a striking memorial in Cedar Hill Cemetery commissioned by his son Charles Wells,  inscribed with the words “There Shall Be No Pain” and “I Awaken To Glory.” Thanks to the idea that occurred to Horace Wells today in 1844, those words have rung true for millions of people all over the world.

The monument to Horace Wells located in Hartford’s Cedar Hill Cemetery.

Further Reading

Emily E. Gifford, “Horace Wells Discovers Pain-Free Dentistry,”

Andrew Brodsky, “Relax, Inhale, and Think of Horace Wells,” Oxford University Press blog

Dr. Horace Wells, 1818 – 1845,” Cedar Hill Cemetery Foundation